The film tells the story of Chandru, a singer who is touring Singapore with his band where he meets his love interest Sona only to find that she is terminally ill. The movie takes a turn when Chandru finds out about Sona’s cancer and decides to grant her final wish of performing on stage with his band. Ninaithale Inikkum was filmed around various locations in Singapore such as Paya Lebar Airport, Mount Faber, Orchard Towers and the Singapore River.

Sathya (Navdeep), Guru (Abhinay) and Sathyan (Sathyan) are friends. Anjali (Sara Alambra), Meghna (Suja), Radhika (Madhumitha) and Anu (Mallika Kapoor) come in Sathya's life. The complication that arises, the tussle with Bhadri Narayanan (Prakash Raj) form the rest of the movie.